Appendix cancer is rare but typically affects individuals between the ages of 40 and 60. Recent trends indicate a rising incidence across all age groups, including younger adults. A major diagnostic challenge with appendix cancer is its symptom similarity to appendicitis, particularly abdominal pain in younger patients, which can delay diagnosis and treatment. In more advanced stages, additional symptoms such as chronic constipation, anemia, fatigue, and weight loss may also develop.
Among the different types of appendiceal cancers, colonic-type adenocarcinomas make up about 60% of cases and are more commonly found in older individuals. On the other hand, appendiceal neuroendocrine tumors (NETs) are rarer and tend to occur more frequently in younger patients, according to Dr. Raman Narang, a senior consultant and medical oncologist at Andromeda Cancer Hospital.
What are neuroendocrine tumors (NETs) in the appendix?
Neuroendocrine tumors (NETs) in the appendix originate from neuroendocrine cells, which have both nerve and hormone functions. When these tumors develop in the appendix, they are often called “carcinoid tumors” due to their distinct biological properties. While NETs are quite rare, they are gaining more recognition thanks to advances in diagnostic techniques and increased awareness.
